The Effect of Several Compounds on the Inhibition of Bacterial Growth by Sulfaguanidine, Sulfamerazine, and Sulfasuxidine

Abstract

The effects of 19 compounds, including vits., amino acids, and structurally related substances on the growth, glucose metabolism, and sulfonamide bacteriostasis of Escherichia coli and Salmonella paratyphi B, were detd. Results differed considerably for the 2 organisms. Nicotinic acid, Ca pantothenate, urea, caffeine, nembutal, uracil, creatine, asparagine, cystine, and tryptophane stimulated, but thiamine and p-aminobenzoic acid inhibited, the growth of S. paratyphi B. Asparagine, cystine, and tryptophane stimulated, but creatine and PABA inhibited the growth of E. coli. Asparagine, cystine, and tryptophane reversed the action of sulfaguanidine, sulfamerazine and sulfasuxidine. Allantoin, thiamine, and urea increased the bacteriostatic action of some of the sulfonamides against one or both test organisms. Stimulation of acid production and sugar utilization in the presence of the sulfonamides was produced by the 3 amino acids that reversed the bacteriostatic action. All growth stimulating compounds for S. paratyphi B were found to increase sugar utilization, but only asparagine, cystine, and tryptophane produced significant changes in acid production.