Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method

Abstract

An emulsification-spray drying technique is used to prepare poly(D, L-lactic acid) (PDLLA) microparticles loaded with a water soluble, non-steroidal antiinflammatory drug (NSAID), sodium naproxen (NaNPX). The method involves the preparation of a w/o emulsion in which the water soluble drug is dissolved in the aqueous dispersed phase, while the polymer is dissolved in the organic continuous phase. As a comparison, microparticles were prepared by spraying a suspension of the drug into an organic solution of the polymer. The spray-dried particles were characterized using SEM, DSC, XRD and in vitro release tests. The spray-dried product was then compressed (direct compression) to obtain controlled release matrix tablets. All microparticles release NaNPX within 30min. The matrix tablets release the drug in 8-10h; the matrix tablets characterized by the presence of surfactant (due to the emulsion used to obtain the microparticles) have the highest release rate.