Teratogenic Effects of Meclizine Hydrochloride on the Rat
- 26 July 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 141 (3578), 353-355
- https://doi.org/10.1126/science.141.3578.353
Abstract
Congenital malformations were induced in the offspring of pregnant Sprague-Dawley rats by the admninistration of relatively large doses of meclizine hydrochloride (Bonine). The critical period of gestation for administration was from the 12th to 15th day. Anomalies were produced in the tongue, palatal closure, mouth, lower jaw, vertebrae and limbs.Keywords
This publication has 5 references indexed in Scilit:
- Meclozine (" Ancoloxin ") and Foetal AbnormalitiesBMJ, 1962
- EXPERIMENTAL PRODUCTION OF CONGENITAL MALFORMATIONS IN STRAINS OF INBRED MICE BY MATERNAL TREATMENT WITH HYPERVITAMINOSIS A1961
- Temporary Uterine Circulatory Arrest as a Cause of Abnormal Fetal DevelopmentJournal of Dental Research, 1960
- Disturbance of Pregnancy in Mouse and Rat by Systemic Antihistaminic TreatmentExperimental Biology and Medicine, 1955
- FAILURE OF AN ANTIHISTAMINE DRUG TO PREVENT PREGNANCY IN THE MOUSEEndocrinology, 1955