Cellular Responses to DNA Damage: One Signal, Multiple Choices
- 1 December 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 40 (1), 187-208
- https://doi.org/10.1146/annurev.genet.40.110405.090428
Abstract
DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.Keywords
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