Clinical Experience with a Human Thyroid Cell Bioassary for Thyroid-Stimulating Immunoglobin *
- 1 February 1984
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 58 (2), 332-338
- https://doi.org/10.1210/jcem-58-2-332
Abstract
A sensitive, specific, and practical bioassay for thyroid-stimulating immunoglobulin (TSI) is now available for clinical use. Fifty-seven of 61 patients with untreated hyperthyroid Graves’ disease were TSI positive (sensitivity, 93%). TSI was undetectable in all normal subjects and in patients with Hashimoto’s thyroiditis (without concurrent Graves’ ophthalmopathy), nontoxic goiter, and toxic nodular goiter (specificity, 100%). The prevalence of TSI in serum declined after therapy, particularly during methimazole or propylthiouracil treatment. TSI correlated well with relapse or remission after antithyroid drug therapy. All 12 patients who were TSI negative at the time of discontinuing antithyroid drug therapy remained in remission (average follow-up of 10 months). TSI values in Graves’ disease correlated better with thyroid dysfunction than with ophthalmopathy. Prenatal TSI activity tended to be higher in mothers of infants who developed neonatal Graves’ disease than in atrisk mothers who delivered normal infants. However, there was considerable overlap between the two groups. (J Clin Endocrinol Metab 58: 332, 1984)Keywords
This publication has 9 references indexed in Scilit:
- THYROID STIMULATING ANTIBODIES (TSAb) IN PATIENTS WITH GRAVES' DISEASE UNDERGOING ANTITHYROID DRUG TREATMENT: INDICATORS OF ACTIVITY OF DISEASEClinical Endocrinology, 1981
- Thyroid-Stimulating Immunoglobulin Bioassay Using Cultured Human Thyroid Cells*Journal of Clinical Endocrinology & Metabolism, 1981
- INFLUENCE OF TREATMENT WITH RADIOIODINE AND PROPYLTHIORACIL ON THYROID STIMULATING IMMUNOGLOBULINS IN GRAVES' DISEASEClinical Endocrinology, 1980
- Carbimazole and the Autoimmune Response in Graves' DiseaseNew England Journal of Medicine, 1980
- Clinical Significance of Assay of Thyroid-Stimulating Antibody in Graves' DiseaseAnnals of Internal Medicine, 1980
- A NEW METHOD FOR MEASUREMENT OF HUMAN THYROID-STIMULATING IMMUNOGLOBULINS1980
- Changes in Thyroid-Stimulating Antibody Activity in Graves' Disease Treated with Antithyroid Drug and Its Relationship to Relapse: A Prospective Study*Journal of Clinical Endocrinology & Metabolism, 1980
- Modification of the Classification of the Eye Changes of Graves' DiseaseAmerican Journal of Ophthalmology, 1977
- Occurrence in Thyrotoxicosis of a Gamma Globulin Which Protects LATS from Neutralization by an Extract of Thyroid GlandJournal of Clinical Endocrinology & Metabolism, 1967