A year ago we reported on the beneficial effect of a diet rich in liver for forty-five patients with pernicious anemia.1 During the year, Brill,2 Sappington3 and Barach4 have reported in confirmation of our results, and Koessler, Maurer and Loughlin5 and Elders6 have likewise emphasized the importance of a diet in the treatment of this disease. Our purpose in this paper is to record further observations on our original patients who have continued to take the diet for from about one to three years, and to add information concerning sixty others, or a total of 105. We will discuss the nature of the effective material and its mode of action. Some of the observations on the 105 patients have been made by other physicians, and we are indebted to them for furnishing us with data. Of the total 105, ninety were placed on the