LRRK2 expression linked to dopamine‐innervated areas
- 10 March 2006
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 59 (4), 714-719
- https://doi.org/10.1002/ana.20808
Abstract
Objective Leucine‐rich repeat kinase 2 (LRRK2) has been linked to Parkinson's disease. Our study explores the expression of LRRK2 in human and rodent brain tissue. Methods We analyzed LRRK2 gene activity at the cellular level using in situ hybridization. Results We found a high and strikingly specific expression of LRRK2 mRNA in rodent striatum and parts of cortex and no signals in dopamine neurons. In human tissue, LRRK2 mRNA was found in the corresponding brain areas caudatus and putamen at lower levels and dopamine neurons were also devoid of LRRK2 mRNA. Expression levels in striatal tissue did not differ between Parkinson's disease patients and control subjects. Interpretation Unlike all other genes so far linked to Parkinson's disease, our results demonstrate that LRRK2 expression is particularly high in brain dopaminoceptive areas. Ann Neurol 2006Keywords
This publication has 12 references indexed in Scilit:
- DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodentsPhysiology & Behavior, 2007
- Pathophysiology, pleotrophy and paradigm shifts: genetic lessons from Parkinson's diseaseBiochemical Society Transactions, 2005
- A Rare Truncating Mutation in ADH1C (G78Stop) Shows Significant Association With Parkinson Disease in a Large International SampleArchives of Neurology, 2005
- Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's DiseaseNeuron, 2004
- Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic PathologyNeuron, 2004
- Loss of response to levodopa in Parkinson’s disease and co-occurrence with dementia: role of D3 and not D2 receptorsBrain Research, 2002
- Further evidence for an association of the Paraoxonase 1 (PON1) Met‐54 allele with Parkinson's diseaseMovement Disorders, 2002
- Alcohol dehydrogenase alleles in Parkinson's diseaseMovement Disorders, 2000
- Expression of ?-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's diseaseAnnals of Neurology, 2000
- Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistryHistochemistry and Cell Biology, 1992