Bile Acids and Steroids. XXIII. Thiosteroids. (8). Intramolecular Condensation of Some 6-Acetylthio Steroids.

Abstract

The 3, 3-ethylenedioxy-5α, 6α-epoxy steroids were converted to the 5α-hydroxy-6β-acetylthio-3-oxo steroids by the action of thiolacetic acid. These were dehydrated, and following by epimerization of the substituent at position 6 converted to 6α-acetylthio-4-en-3-one steroids. The thiophene derivatives were obtained from the last mentioned compounds by the action of basic alumina.