Synthesis of 2′,3′-Dideoxycyclopentenyl Carbocyclic Nucleosides as Potential Drugs for the Treatment of AIDS
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 6 (1-2), 239-244
- https://doi.org/10.1080/07328318708056196
Abstract
The recently discovered antiviral activity of 2′,3′-dideoxy-nucleosides against the AIDS virus in vitro prompted the synthesis of 2′,3′-dideoxycyclopentenyl adenine and cytosine. A sequence of two consecutive reductive deoxygenations using 1,1′-thiocarbonyldiimidazole followed by reduction with tributyl tin hydride afforded the desired target compounds. Neither compound showed activity in the in vitro assay against the HTLV-III/LAV virus.Keywords
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