A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF
- 22 February 1991
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 251 (4996), 936-939
- https://doi.org/10.1126/science.1840698
Abstract
Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation.Keywords
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