Blood-brain barrier integrity and host responses in experimental metastatic brain tumours
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in Clinical & Experimental Metastasis
- Vol. 1 (3), 229-246
- https://doi.org/10.1007/bf00736407
Abstract
The effect of brain implants of Walker 256 carcinosarcoma tumour cells on the integrity of the blood-brain barrier was examined in rats using labelled albumin, horseradish peroxidase and trypan blue. Barrier integrity was intact within 1 hour of implantation but was gradually reduced within the tumour after 3·5 days. This was related to alterations in the fine structure of the tumour capillaries. Dissociated tight junctions were apparent within the tumour centre, but no fenestrated endothelium or gap junctions were observed by electron microscopy.This publication has 37 references indexed in Scilit:
- INTRACELLULAR SERUM PROTEINS IN CEREBRAL GLIOMAS AND METASTATIC TUMOURS: AN IMMUNOPEROXIDASE STUDYNeuropathology and Applied Neurobiology, 1978
- A new specific, sensitive and non-carcinogenic reagent for the demonstration of horseradish peroxidaseJournal of Molecular Histology, 1977
- THE DEVELOPMENT AND ULTRASTRUCTURE OF THE MICROVASCULATURE IN MALIGNANT GLIOMASNeuropathology and Applied Neurobiology, 1977
- Brain Changes and Survival of Animals with Tumors Implanted in the BrainOncology, 1975
- FRACTURE FACES OF OSMOTICALLY DISRUPTED ZONULAE OCCLUDENTESThe Journal of cell biology, 1974
- THE STRUCTURE OF THE ZONULA OCCLUDENSThe Journal of cell biology, 1974
- AN INTERPRETATION OF LIVER CELL MEMBRANE AND JUNCTION STRUCTURE BASED ON OBSERVATION OF FREEZE-FRACTURE REPLICAS OF BOTH SIDES OF THE FRACTUREThe Journal of cell biology, 1970
- FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASEThe Journal of cell biology, 1967
- The Permeability of Brain Capillaries to Non‐ElectrolytesActa Physiologica Scandinavica, 1965
- THE INFLUENCE OF CARBON DIOXIDE INHALATION ON THE CEREBRAL VASCULAR PERMEABILITY TO TRYPAN BLUE (‘THE BLOOD‐BRAIN BARRIER’)Acta Pathologica Microbiologica Scandinavica, 1958