The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
- 1 May 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 339 (6222), 280-286
- https://doi.org/10.1038/339280a0
Abstract
We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.Keywords
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