Characterization of carbohydrates in the α2-macroglobulin receptor
- 29 June 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 305 (2), 129-132
- https://doi.org/10.1016/0014-5793(92)80879-l
Abstract
Carbohydrates were characterized in the human placental α2-macroglobulin receptor and its associated protein. Carbohydrates, largely N-linked, contributed to about 18% of the size of the receptor α-chain and to about 25% of the β-chain. The 40 kDa receptor-associated Protein also contained carbohydrate. The α- and β-chains contained a wide variety of carbohydrates as judged by binding of lectins. Monosaceharide-competing inhibition of α2M-methylamine binding by WGA suggested a functional significance of sugars in binding of ligands to the α-chainKeywords
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