Isolated perfusion is of established effectiveness in Melanoma the treatment of recurrent melanoma, particularly of the extremities. 105 perfusion operations were performed on 92 patients in the past 12 years. 44 of these patients had recurrent melanoma of the extremities and 10 (22%) are free of disease 7 to 124 months postoperative. In this group the five-year survival is 35%. Perfusion was employed as an adjunct to surgical excision therapy for primary melanoma in 39 patients, 27 (69%) are free of disease with a five-year survival rate of 73%. However, no conclusion is reached as to the value of this procedure as an adjuvant to surgical excision.