Myopathy with abnormal structure and function of muscle mitochondria.
Open Access
- 1 December 1967
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 30 (6), 519-525
- https://doi.org/10.1136/jnnp.30.6.519
Abstract
A case of myopathy involving the proximal muscles is described in a 27-month-old girl. Light microscope study revealed the presence of muscle fibers of very small diameter containing fine, granulated material. High activity of oxidative enzymes was seen in these small fibers. Electron microscopic study revealed numerous mitochondria. Many of these were abnormal in shape and in size. Biochemical studies of isolated mitochondrial fractions showed loose coupling of oxidative phosphorylation.This publication has 12 references indexed in Scilit:
- SKELETAL MUSCLE DISEASE WITH ABNORMAL MITOCHONDRIABrain, 1967
- Electron microscopic study of the toxic effect of sodium fluoroacetate on rat myocardial culturesExperimental Cell Research, 1966
- TWO CHILDHOOD MYOPATHIES WITH ABNORMAL MITOCHONDRIABrain, 1966
- ULTRASTRUCTURAL OBSERVATIONS OF SKELETAL MUSCLE IN MYOPATHY AND NEUROPATHY WITH SPECIAL REFERENCE TO MUSCULAR DYSTROPHY1966
- EFFECTS OF CHRONIC PROTEIN DEFICIENCY IN RATS .2. BIOCHEMICAL AND ULTRASTRUCTURAL CHANGES1966
- A CASE OF SEVERE HYPERMETABOLISM OF NONTHYROID ORIGIN WITH A DEFECT IN THE MAINTENANCE OF MITOCHONDRIAL RESPIRATORY CONTROL: A CORRELATED CLINICAL, BIOCHEMICAL, AND MORPHOLOGICAL STUDYJournal of Clinical Investigation, 1962
- A MODIFIED PROCEDURE FOR LEAD STAINING OF THIN SECTIONSThe Journal of cell biology, 1961
- Dégénérescence myélinique des mitochondries de foie humain dans un épithélioma du cholédoque et un ictère viralJournal of Ultrastructure Research, 1959
- Enzymic Activities of Human Skeletal Muscle Mitochondria: A Tool in Clinical Metabolic ResearchNature, 1959
- Mitochondrial Changes in the Adrenocortex of Normal HamstersThe Journal of cell biology, 1958