AN ISOMORPHOUS HEAVY ATOM SUBSTITUTION AT THE ACTIVE SITE OF GAMMA-CHYMOTRYPSIN
- 1 June 1964
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 51 (6), 1146-1151
- https://doi.org/10.1073/pnas.51.6.1146
Abstract
An irreversible inhibitor, p-iodobenzenesulfonyl fluoride, has been used to prepare a crystalline single site heavy atom derivative of [gamma] CHT which is isomorphous with crystalline p-toluenesulfonyl- [gamma] CHT. The coordinates of the heavy atom, iodine, have been derived from 4 A difference Patterson projections.Keywords
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