Effects of perfusate constituents on transmucosal fluid movement and drug absorption in rat small intestine.

Abstract

Effects of various constituents of the perfusates on the sulfanilamide absorption were investigated using in situ recirculation perfusion method with the rat small intestine. Constituents employed were salts and chemicals which were used as components in various buffer solutions and these salts were used in a single or in combination with each other. Both the absorption and the transmucosal fluid movement were considerably influenced by the constituents of the perfusates. Some salts exhibited lethal effects during the course of the experiment.