LIPID METABOLISM IN EXPERIMENTAL PANCREATIC DIABETES I. BLOOD AND LIVER LIPIDS OF DOGS FASTED DURING TOTAL INSULIN DEPRIVATION1

Abstract

Two types of completely depancreatized dogs observed for the effects of insulin deprivation during fasting. During the period immediately following pancreatectomy 1 group received insulin and a diet adequate in calories, proteins, salts and vits., but lacking raw pancreas. The 2d group received insulin and a diet containing raw pancreas in addition to the above dietary constituents. A hyperlipemia need not occur in the dog when insulin is excluded during fasting. In dogs that had received no raw pancreas before cessation of insulin treatments, the initially low levels of cholesterol, phospholipid and total fatty acids were maintained or rose slightly. In depancreatized dogs that had been fed raw pancreas before withdrawal of insulin, a decided fall in the lipid level of the blood was the usual finding.