Vitamin D and calcium interactions: functional outcomes
Open Access
- 1 August 2008
- journal article
- review article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 88 (2), 541S-544S
- https://doi.org/10.1093/ajcn/88.2.541s
Abstract
I present the results of published studies and original data and describe the functional outcomes of effects related to the interaction between vitamin D status and calcium intake. These effects fall into 3 broad categories: 1) synergistic effects of vitamin D status and calcium intake on calcium absorption; 2) effects of calcium intake on vitamin D status; and 3) largely observational data suggesting an association between calcium and vitamin D status and nonskeletal outcomes, such as cancer. To a considerable extent, both vitamin D status and the benefits associated therewith appear to be dependent on, or at least augmented by, calcium intakes at or above currently recommended levels.Keywords
This publication has 28 references indexed in Scilit:
- Plasma 25-Hydroxyvitamin D Levels and Risk of Incident HypertensionHypertension, 2007
- The case for improving vitamin D statusThe Journal of Steroid Biochemistry and Molecular Biology, 2007
- The Vitamin D requirement in health and diseaseThe Journal of Steroid Biochemistry and Molecular Biology, 2005
- Vitamin D and Calcium Intakes from Food or Supplements and Mammographic Breast DensityCancer Epidemiology, Biomarkers & Prevention, 2005
- Calcium Supplements for the Prevention of Colorectal AdenomasNew England Journal of Medicine, 1999
- A Clinical Trial of the Effects of Dietary Patterns on Blood PressureNew England Journal of Medicine, 1997
- Determinants of endogenous fecal calcium in healthy womenJournal of Bone and Mineral Research, 1994
- The role of 1,25‐dihydroxyvitamin D in the mechanism of acquired vitamin D deficiencyClinical Endocrinology, 1992
- Effect of calcium intake on serum levels of 25‐hydroxyvitamin D3European Journal of Clinical Investigation, 1988
- A new mechanism for induced vitamin D deficiency in calcium deprivationNature, 1987