METABOLISM OF 4-C14-CORTICOSTERONE IN MAN*†
- 1 October 1956
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 16 (10), 1291-1298
- https://doi.org/10.1210/jcem-16-10-1291
Abstract
Cortisol (17-hydroxycorticosterone) is presently accepted as being the main corticosteroid secreted by the adrenal gland of man. It has been recently isolated from human adrenal vein blood by Romanoff et al. (1) and evidence has been presented that it is the main free corticosteroid in the peripheral plasma of adult human subjects (2, 3). Corticosterone, however, has also been isolated from human adrenal vein blood (1). It is probably present in peripheral plasma as well, but the value of the ratio of cortisol to corticosterone has been the subject of controversy; Morris and Williams (4) and Sweat et at. (5) reported ratios of approximately 1, whereas Bush and Sandberg (2) and Pincus and RomanKeywords
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