An overview of pharmacologic treatment of cognitive decline in the aged
- 1 May 1981
- journal article
- clinical trial
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 138 (5), 593-600
- https://doi.org/10.1176/ajp.138.5.593
Abstract
The most widely known substances that have been investigated for treating cognitive deterioration in the aged are cerebral vasodilators, Gerovital H3, psychostimulants, "nootropics," neuropeptides, and neurotransmitters. The rationale for the choice of specific agents has shifted as our conceptions regarding the origins of cognitive decline have changed; we now know that most cognitive deterioration occurs independently of arteriosclerotic vascular changes. Substances currently being investigated because of their effects on brain electrophysiology, on neurohumoral processes, or on central neurotransmitters show promise.Keywords
This publication has 51 references indexed in Scilit:
- The Effects of Hyperbaric and Normobaric Oxygen on Cognitive Impairment in the ElderlyArchives of General Psychiatry, 1978
- Neurotransmitter enzyme abnormalities in senile dementiaJournal of the Neurological Sciences, 1977
- Memory Enhancement After Physostigmine Treatment in the Amnesic SyndromeArchives of Neurology, 1977
- Senile Dementia and Drug TherapyPublished by Springer Nature ,1977
- Increase in the power of human memory in normal man through the use of drugsPsychopharmacology, 1976
- Pharmacological protection against hypoxia induced amnesia in ratsPsychopharmacology, 1971
- Observations on the brains of non-demented old peopleJournal of the Neurological Sciences, 1968
- Carbonic Anhydrase Inhibition and Cerebral Venous Blood Gases and Ions in ManArchives of Internal Medicine, 1966
- Influence of Acetazolamide on Cerebral Blood FlowArchives of Neurology, 1961
- DOUBLE-BLIND EVALUATION OF METHYLPHENIDATE (RITALIN) HYDROCHLORIDEJAMA, 1959