Molecular Characterization of125I Decay and X-ray-induced HPRT Mutants in CHO Cells
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 51 (2), 193-199
- https://doi.org/10.1080/09553008714550691
Abstract
The predominant initial lesion induced by 125I decay in DNA is a double-strand DNA break comprising a ‘mini deletion’ of up to several base pairs (bp). However, Southern analysis of the structure of 125I decay-induced HPRT mutants in Chinese hamster ovary cells revealed that most of the mutants are deletions of thousands of bps. A similar predominance of substantial deletions was also found in X-ray-induced mutants.Keywords
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