Effect of Ablation of the Subfornical Organ on Water Intake Elicited by Systemically Administered Angiotensin-II

Abstract

The effect of electrolytic lesions of the subfornical organ on water intake induced by the continuous infusion of angiotensin-II through a chronic jugular cannula was studied. Lesions of the subfornical organ significantly reduced but did not abolish the elicited drinking. These results support the hypothesis that the subfornical organ is a receptor site for angiotensin-II but also suggest that this may not be the only site of receptors.