Alterations of Surface Properties of Chick Embryo Fibroblasts Infected with Four Rous Sarcoma Viruses Producing Distinctive Cell Transformation

Abstract

Four cloned strains of RSV producing different morphological changes and varying degrees of loss of contact inhibition of chick embryo fibroblasts on infection and transformation of these cells in vitro induce similar marked elevations in the activities of the UDP-galactose and GDP-mannose glycosyl transferase ectoenzyme systems when compared to normal or RAV-1 infected cells. Such transformed cells also exhibit significant elevations in their electrophoretic mobilities when compared to control or RAV-1 infected cells. Thus the type of morphological change or the degree of loss of contact inhibition is not related to these cell surface changes in RSV transformed cells.