Isolation and structure of antipeptic ulcer diterpene from Thai medicinal plant.

Abstract

A potent antipeptic ulcer substance, acyclic diterpene alcohol, was isolated from a Thai medicinal plant identified as Croton sublyratus and was tested in the rat. The structure was determined by the spectral data and stereospecific synthesis to be (E,Z,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol.