Extracts of dog olfactory mucosa were subjected to affinity chromatography on columns having exposed methoxyphenyl groups. Elution with p-anisic acid displaced a protein component demonstrable with polyacrylamide gel electrophoresis. This was present in larger amount in extracts made with the detergent, sodium dodecyl sulfate, than in detergent-free extracts, suggesting that it had originated in some membranous structure. It was not seen in extracts of nearby respiratory epithelium. It is hypothesized that this includes a recognition molecule through which odorants such as anisole stimulate olfactory receptors.