Cysteamine: a Potent and Specific Depletor of Pituitary Prolactin
- 30 July 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4558), 452-454
- https://doi.org/10.1126/science.7089575
Abstract
Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.This publication has 22 references indexed in Scilit:
- Cysteamine reduces serum gonadotropin concentrations in adult male ratsLife Sciences, 1982
- Estrogen Alters the Responsiveness of the Anterior Pituitary Gland to the Actions of Dopamine on Lysosomal Enzyme Activity and Prolactin Release*Endocrinology, 1981
- A Possible Role for Lysosomes in the Inhibitory Action of Dopamine on Prolactin Release*Endocrinology, 1981
- Effects of Cysteamine Therapy in Nephropathic CystinosisNew England Journal of Medicine, 1981
- Tuberoinfundibular dopamine neurons and the regulation of prolactin secretionPsychoneuroendocrinology, 1981
- Pathogenesis of duodenal ulceration produced by cysteamine or propionitrileDigestive Diseases and Sciences, 1979
- New Drugs: Bromocriptine and Endocrine DisordersAnnals of Internal Medicine, 1979
- Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivo.Journal of Clinical Investigation, 1976
- [5] In vitro pituitary hormone secretion assay for hypophysiotropic substancesMethods in Enzymology, 1975
- Experimental Model for Production of Perforating Duodenal Ulcers by Cysteamine in the RatNature, 1973