Covalent modification and metabolic control analysis
- 1 July 1990
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 191 (2), 405-411
- https://doi.org/10.1111/j.1432-1033.1990.tb19136.x
Abstract
A study of the sensitivity properties of metabolic systems containing covalently modifiable enzymes and cascades has been carried out with the aid of metabolic control analysis. We have considered how the theorems of metabolic control analysis must be modified to take into account covalently modifiable enzymes, and have used these results to investigate the effects of increasing the total amount of modifiable enzyme. The sensitivity of system variables to an effector acting through a covalent‐modification cycle has also been investigated.This publication has 26 references indexed in Scilit:
- Enzyme‐enzyme interactions and control analysisEuropean Journal of Biochemistry, 1990
- Enzyme‐enzyme interactions and control analysisEuropean Journal of Biochemistry, 1990
- Control analysis of metabolic networksEuropean Journal of Biochemistry, 1988
- Control of metabolism: What do we have to measure?Trends in Biochemical Sciences, 1987
- Metabolic control analysis of moiety‐conserved cyclesEuropean Journal of Biochemistry, 1986
- Control analysis of metabolic systemsTrends in Biochemical Sciences, 1985
- Is phosphofructokinase the rate-limiting step of glycolysis?Trends in Biochemical Sciences, 1984
- Regulation of enzyme activity by cyclic phosphorylation-dephosphorylation cascadesBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
- Sensitivity amplification in biochemical systemsQuarterly Reviews of Biophysics, 1982
- Allosteric proteins and cellular control systemsJournal of Molecular Biology, 1963