Apomorphine: Modification of Its Hyperthermic Effect in Rabbits by p -Chlorophenylalanine
- 8 February 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4124), 539-540
- https://doi.org/10.1126/science.183.4124.539
Abstract
The hyperthermic response of rabbits to apomorphine, a dopaminergic agonist, is abolished by prior treatment with p-chlorophenylalanine. If such 5-hydroxytryptamine (5-HT)-depleted animals are administered a peripherally acting decarboxylase inhibitor plus 5-hydroxytryptophan, central stores of 5-HT are regenerated and the hyperthermic response to apomorphine is restored in part. The effects of apomorphine in rabbits with elevated concentrations of 5-HT are not different from those in control animals. The behavioral effects of apomnorphine appear to be constant in all groups of animals tested. It is suggested that the hyperthermic effects of apomorphine in rabbits require the presence of 5-HT.Keywords
This publication has 5 references indexed in Scilit:
- Possible involvement of brain serotonin in apomorphine-induced hypothermiaEuropean Journal of Pharmacology, 1973
- Absence of serotonergic influence on apomorphine-induced stereotypyEuropean Journal of Pharmacology, 1972
- Receptor activity and turnover of dopamine and noradrenaline after neurolepticsEuropean Journal of Pharmacology, 1970
- Behavioural Stereotypies Induced by Pharmacological AgentsPharmacopsychiatry, 1968
- Mode of action of apomorphine and dexamphetamine on gnawing compulsion in ratsPsychopharmacology, 1967