ON THE EXCRETION OF SKIODAN, DIODRAST AND HIPPURAN BY THE DOG

Abstract

Clearances of 3 organic compounds of iodine, skiodan, diodrast and hippuran, were compared to that of creatinine in the dog. The clearance of skiodan is independent of the concn. of this substance in the plasma, and is consistently less than that of creatinine by approximately 10%. The clearances of diodrast and hippuran are strictly dependent upon the concn. of these substances in the plasma. At high plasma iodine levels their clearances approximate that of creatinine, at low plasma iodine levels they exceed that of creatinine several fold. The results are interpreted to indicate that the elimination of skiodan may be attributed to glomerular nitration alone, while the excretion of diodrast and hippuran requires the postulation of tubular secretion.