IDENTIFICATION OF TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN PRIMARY BREAST CARCINOMAS
- 1 November 1987
- journal article
- research article
- Vol. 7 (6), 1271-1275
Abstract
Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus indentified as Tumor Growth Factor (TGF) alpha, could be identified in 25% of the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.This publication has 13 references indexed in Scilit:
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