Gall Stones in Patients with Disorders of the Terminal Ileum and Disturbed Bile Salt Metabolism
- 30 August 1969
- Vol. 3 (5669), 494-496
- https://doi.org/10.1136/bmj.3.5669.494
Abstract
In a combined historical and radiological survey gall stones were found in 23 out of 72 patients with disorders of the terminal ileum (31·9%). This is four to five times the expected incidence of cholelithiasis. In these patients the incidence of gall stones was not related to age, but did, however, increase with increased duration of the ileal disorder. Glycine/taurine conjugation ratios of bile salts in the bile were abnormally high in 10 out of 11 patients with ileal disorders. Both impaired bile salt recirculation and absorption of poorly soluble bacterially degraded bile salts are possible causes of cholelithiasis in these patients.Keywords
This publication has 21 references indexed in Scilit:
- BILE-SALT DECONJUGATION AND STEATORRHŒA IN PATIENTS WITH THE STAGNANT-LOOP SYNDROMEThe Lancet, 1968
- BILE-SALTS IN SMALL INTESTINAL CONTENTS AFTER ILEAL RESECTION AND IN OTHER MALABSORPTION SYNDROMESThe Lancet, 1968
- Bile-Salt Deficiency in the Steatorrhea Following Resection of the Ileum and Proximal ColonNew England Journal of Medicine, 1967
- Importance of Bile Acids and of an Intact Distal Small Intestine for Fat AbsorptionGastroenterology, 1967
- Production of bile duct hyperplasia and gallstones by lithocholic acid.JCI Insight, 1966
- Floating gallbladder calculi: Their incidence in a review of one thousand cholecystogramsThe American Journal of Surgery, 1963
- Gallstones in an autopsy series. Incidence, complications, and correlations with carcinoma of the gallbladder.1960
- Regional Enteritis: Associated Visceral ChangesGastroenterology, 1956
- Cholecystography; observations on the technique of the examination and the interpretation of its results.1953
- THE INCIDENCE OF GALLSTONES AND THEIR CORRELATION WITH OTHER DISEASESAnnals of Surgery, 1952