Vasoactive Intestinal Peptide: A Possible Transmitter of Nonadrenergic Relaxation of Guinea Pig Airways
- 12 December 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4475), 1252-1253
- https://doi.org/10.1126/science.6254154
Abstract
Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.Keywords
This publication has 25 references indexed in Scilit:
- Bronchodilatation: Noncholinergic, Nonadrenergic Mediation Demonstrated in Vivo in the CatScience, 1980
- In Vivo Demonstration of Nonadrenergic Inhibitory Innervation of the Guinea Pig TracheaJournal of Clinical Investigation, 1980
- A rich VIP nerve supply is characteristic of sphinctersNature, 1979
- Specific Binding of Vasoactive Intestinal Peptide to Brain Membranes from the Guinea PigEuropean Journal of Biochemistry, 1978
- Vasoactive Intestinal Polypeptide: Abundant Immunoreactivity in Neural Cell Lines and Normal Nervous TissueScience, 1976
- Demonstration of a nonadrenergic inhibitory nervous system in the trachea of the guinea pigJournal of Allergy and Clinical Immunology, 1975
- Nature of the vagal inhibitory innervation to the lower esophageal sphincter.Journal of Clinical Investigation, 1975
- Neural Control of the Lower Esophageal Sphincter INFLUENCE OF THE VAGUS NERVESJournal of Clinical Investigation, 1974
- HUMORAL CONTROL OF AIRWAYS*Annals of the New York Academy of Sciences, 1974
- Some observations on the intrinsic nervous mechanism in Hirschsprung's diseaseGut, 1973