Hemodynamics of Pancreatic Secretion

Abstract

SEVERAL earlier studies have been carried out on the relationship between pancreatic secretion and pancreatic blood flow. In 1856, Claude Bernard¹ observed swelling and a reddish color change in the pancreas during digestion. In 1928 Weaver² made a crude estimation of pancreatic blood flow after secretin administration by resecting the tail of the pancreas and recording the rate of blood flow from the pancreatic vein issuing from the tail of the pancreas. Maltesos and Watson,³ using the thermostromuhr of Rein, reported that during pancreatic secretion induced by either secretin administered intravenously or hydrochloric acid administered intraduodenally, the pancreatic blood flow was increased. Bennett and Still,⁴ by measuring pancreatic vein outflow, observed an increase in flow concomitant with increased pancreatic duct pressure. Tankel and Hollander⁵ in a review of the subject stated that it was their opinion that there was presently no evidence available to indicate