Trace Metal-Citric Acid Complexes as Inhibitors of Calcification and Crystal Growth
- 1 December 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 128 (6), 1376-1378
- https://doi.org/10.1016/s0022-5347(17)53511-9
Abstract
The high molecular weight Fe (III)-citric acid complex, formed at low ratios of citrate:iron in solution, has been shown to be an effective inhibitor of calcium oxalate crystal growth. This appears to be a specific reaction, since 2 other similar metal ions, Al(III) and Cr(III), exhibit no synergism with citric acid in this system. Because the low molecular weight Fe (III)-citric acid complex, formed at high ratios of citratedron, inhibits calcium phosphate precipitation but has no effect on calcium oxalate, the Fe (III)-citric acid system might have a selective biologic role in regulating the growth of calcium-containing urinary calculi in vivo.This publication has 21 references indexed in Scilit:
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