Blood chemistry in alloxan diabetic rabbits.

Abstract

As a preliminary study of pharmacokinetic behaviors of drugs in alloxan diabetes, endogenous physiological parameters such as levels of glucose and acetone bodies in blood and total protein, albumin and insulin levels in serum were determined employing rabbits under normal and alloxan diabetic conditions. Levels of glucose, acetone bodies, total protein and albumin were increased under alloxan diabetic conditions. The increases were reduced to the normal levels by insulin treatment. From changes of blood glucose levels, insulin levels, total protein and albumin in serum and body weight after ceasing insulin treatment, the stages of hyperglycemia as well as hyperproteinemia and hyperalbuminemia were considered suitable for the study of pharmacokinetic behaviors of drugs in alloxan diabetic rabbits.