Differentiation of a rat mammary cell line in vitro.

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Abstract
The development of fusiform (probably related to myoepithelial) cells was studied in Rama 25 [rat mammary cancer] cultures. They are generated from special differentiated structures (projections) that contain a rapidly differentiating cell type (F-precursor cells). Clonal sublines isolated from projections develop in several directions under both environmental and genetic control. Some types of differentiation are reversible; others are irreversible. The various cell types occurring in vitro may correspond to specific cell types in vivo.
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