Circulating 17-Hydroxyeorticosteroids in Ascorbic Acid-Deficient Guinea Pigs.

Abstract
Plasma 17-hydroxycorticosteroid concns. in scorbutic guinea pigs were elevated 10-fold over levels in control groups. Scorbutic guinea pigs treated with ascorbic acid for 5 days prior to sacrifice had steroid levels comparable to the controls. It appears that 17-hydroxycorticosteroids can be produced by adrenal glands nearly devoid of ascorbic acid.