Prognostic factors in patients with resected stage I non-small cell lung cancer. A report from the Lung Cancer Study Group
- 1 November 1984
- Vol. 54 (9), 1802-1813
- https://doi.org/10.1002/1097-0142(19841101)54:9<1802::aid-cncr2820540908>3.0.co;2-4
Abstract
The authors present prognostic information on recurrence and survival for resected Stage I lung cancer patients with squamous cell carcinoma, adenocarcinoma or large cell carcinoma. The data derive from 392 carefully staged patients and include results from the history and physical examination, preoperative laboratory tests, nature of the surgery, complications, initial pathologic findings following surgical resection, and final pathologic review. A simple multivariate model of recurrence, which is used to classify patients into low, intermediate, and high-risk groups, is based on tumor size and location (T1, T2), histologic type (squamous, nonsquamous/mixed) and nodal status (N0, N1). To model survival, the performance status and the presence of empyema, pneumonia, or wound infection were added to the previous factors. Not all factors associated with increased mortality are associated with increased risk of recurrence, and, in particular, postoperative empyema, pneumonia or wound infections carry an increased risk of death only. Serial measurements of performance status and leukocyte count have the potential for monitoring for increased risk of recurrence and death.This publication has 16 references indexed in Scilit:
- Surgical adjuvant intrapleural BCG treatment for Stage I non-small cell lung cancerThe Journal of Thoracic and Cardiovascular Surgery, 1981
- A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. thyroid cancer cooperative groupEuropean Journal of Cancer (1965), 1979
- The value of carcinoembryonic antigen in patients with carcinoma of the lungCancer, 1979
- Prognostic value of preoperative carcinoembryonic antigen (CEA) plasma levels in patients with bronchogenic carcinomaCancer, 1978
- Trend and homogeneity analyses of proportions and life table dataComputers and Biomedical Research, 1977
- REGIONAL IMMUNOTHERAPY OF LUNG CANCER WITH INTRAPLEURAL B.C.G.The Lancet, 1976
- A SYSTEM FOR THE CLINICAL STAGING OF LUNG CANCERAmerican Journal of Roentgenology, 1974
- Maximum utilization of the life table method in analyzing survivalJournal of Chronic Diseases, 1958
- The use of the nitrogen mustards in the palliative treatment of carcinoma.With particular reference to bronchogenic carcinomaCancer, 1948