IMMUNIZATION AGAINST BRUCELLA INFECTION VI.Brucella melitensis

Abstract

Injection of 109 living cells into non-pregnant goats protected the animals (13/13) from infection and abortion which in unvaccinated animals (12/13) was the characteristic response to the injection of 33 ID50 doses of the challenge strain of B. melitensis (ID93). Temporary agglutination titers in response to the injection of the vaccine strain were produced, which slowly dis-appeared,however, within 3 months after vaccination. The vaccine strain persisted in the lymph nodes of vaccinated animals for 3 months.