Prostatic Neoplasms of the Wistar Rat Induced with 20 - Methylcholanthrene

Abstract

Prostatic tumors, which have never been reported to occur spontaneously in the rat, in contrast to man and dog, were induced in the ventral lobe of the prostate glands of Wistar rats using methylcholanthrene crystals. Intraprostatic de posits of 20-methylcholanthrene induced adenocarcinomas (2%), leio- myosarcomas (3%,) and squamous cell carcinomas (30.3%). The squamous cell and adenocarcinoma metastasized. A detailed account of the distribution of invasion and/or metastases of these prostatic tumors to various organs are presented as well as an account on the growth characteristics of transplantable squamous cell carcinomas.