Comparison between the effects of dietary fat level and of calorie intake on methylnitrosourea-induced mammary carcinogenesis in female sd rats
- 15 June 1987
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 39 (6), 737-744
- https://doi.org/10.1002/ijc.2910390614
Abstract
The aim of this study was to separate the effects of calorie intake on tumorigenesis from those of fat content and fat composition in an animal model. Our principal observations were the following. (1) Decreasing the calorie level by 30% significantly inhibited tumor development in any observed parameter of tumorigenesis, independently of the level of fat. (2) The fat content of semi‐synthetic diets, although varying by 44.4%, did not significantly influence mammary tumorigenesis; in fact, carcinogenic expression was discontinuously related to the fat level. A plateau of tumor incidence was observed at the level of 35 energy percentage of fat. (3) Fat composition did not influence tumorigenesis or body weight gain. The role of caloric restriction is thus stressed in relation to possible dietary prevention of cancer.This publication has 45 references indexed in Scilit:
- Inhibition of the development of radiation-induced leukemia in mice by reduction of food intake.Proceedings of the National Academy of Sciences, 1986
- Effects of Dietary Lipid Saturation on Prolactin Secretion, Carcinogen Metabolism and Mammary Carcinogenesis in RatsJournal of Nutrition, 1984
- The Combined Effects of Dietary Protein and Fat on 7,12-Dimethylbenz(a)anthracene-Induced Breast Cancer in RatsJournal of Nutrition, 1984
- Dietary advice in regard to risk for colon and breast cancerPreventive Medicine, 1980
- Breast-cancer incidence and mortality rates in different countries in relation to known risk factors and dietary practicesBritish Journal of Cancer, 1979
- The association of body weight with recurrent cancer of the breastCancer, 1978
- Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practicesInternational Journal of Cancer, 1975
- Changing Incidence of Breast Cancer in Japanese-American Women2JNCI Journal of the National Cancer Institute, 1973
- Environmental Factors and Cancer of the Colon and BreastBritish Journal of Cancer, 1973
- Effects of level and type of dietary fat on incidence of mammary tumors induced in female sprague‐dawley rats by 7,12‐dimethylbenz(α) anthraceneLipids, 1971