Three cases of pernicious anemia with diabetes mellitus have been reported by S. F. Adams.1These constituted the only ones in a five year period at the Mayo Clinic, including approximately 1,000 cases of pernicious anemia and 2,000 cases of diabetes mellitus. Another case is reported herewith. The patient died from pernicious anemia in March, 1925, eighteen months after she first came under observation. As in Dr. Adams' cases, insulin was used, but instead of proving useless, adequate response was obtained, probably because it was a milder type or was discovered early enough. REPORT OF CASE History. —A woman, aged 55, the mother of four healthy grown-up children, had always been in robust health up to her fiftieth year. In September, 1923, when she first came under observation, she had a fairly severe attack of influenza. The same year the menopause occurred, without noteworthy disturbance. In February, 1922, she