Molecular paleontology and complexity in the last eukaryotic common ancestor
Open Access
- 19 April 2013
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Biochemistry and Molecular Biology
- Vol. 48 (4), 373-396
- https://doi.org/10.3109/10409238.2013.821444
Abstract
Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental evolutionary transitions in the history of life on earth. This event, which is estimated to have occurred over one billion years ago, remains rather poorly understood. While some well-validated examples of fossil microbial eukaryotes for this time frame have been described, these can provide only basic morphology and the molecular machinery present in these organisms has remained unknown. Complete and partial genomic information has begun to fill this gap, and is being used to trace proteins and cellular traits to their roots and to provide unprecedented levels of resolution of structures, metabolic pathways and capabilities of organisms at these earliest points within the eukaryotic lineage. This is essentially allowing a molecular paleontology. What has emerged from these studies is spectacular cellular complexity prior to expansion of the eukaryotic lineages. Multiple reconstructed cellular systems indicate a very sophisticated biology, which by implication arose following the initial eukaryogenesis event but prior to eukaryotic radiation and provides a challenge in terms of explaining how these early eukaryotes arose and in understanding how they lived. Here, we provide brief overviews of several cellular systems and the major emerging conclusions, together with predictions for subsequent directions in evolution leading to extant taxa. We also consider what these reconstructions suggest about the life styles and capabilities of these earliest eukaryotes and the period of evolution between the radiation of eukaryotes and the eukaryogenesis event itself.Keywords
This publication has 295 references indexed in Scilit:
- To the pore and through the pore: A story of mRNA export kineticsBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012
- Connecting Threads: Epigenetics and MetabolismCell, 2012
- Clathrin-independent endocytosis: mechanisms and functionCurrent Opinion in Cell Biology, 2011
- Building the CentrioleCurrent Biology, 2010
- Molecular mechanism and physiological role of pexophagyFEBS Letters, 2010
- Structure of a Bacterial Dynamin-like Protein Lipid Tube Provides a Mechanism For Assembly and Membrane CurvingCell, 2009
- Reconstructing the Evolution of the Endocytic System: Insights from Genomics and Molecular Cell BiologyPublished by Springer Nature ,2006
- The Evolution of Eukaryotic Cilia and Flagella as Motile and Sensory OrganellesPublished by Springer Nature ,2006
- Evolutionary history and higher order classification of AAA+ ATPasesJournal of Structural Biology, 2003
- On the origin of mitosing cellsJournal of Theoretical Biology, 1967