Cyclic Activity In Sleep of Macaca Mulatta

Abstract

Introduction RECENT observations have demonstrated in adult man a basic physiologic periodicity during sleep of 80-90 minutes,^1-3 in the adult cat 20-25 minutes^4-6 and in the adult rat 13 minutes.⁷ These cycles consist of alternation of a high voltage slow wave stage with a low voltage fast frequency cortical electroencephalographic sleep stage, the latter occupying 15%-25% of sleep time. Characteristic alterations in a number of autonomic and somatic motor functions have been found to correlate with the EEG pattern.^8,9 In this study observations of the periodic EEG and behavioral sleep patterns of Macaca mulatta are reported. Method Five M mulatta monkeys, (5-8 lb) had cortical and subcortical electrodes implanted under anesthesia for chronic recordings. The cortical electrodes (three-eighth inch silver discs) were placed on the dura mater through burr holes in the skull and cemented in place with acrylic central cement. Bipolar stainless steel electrodes