Metabolic clearance rate of radioiodinated human calcitonin in man
Open Access
- 1 December 1970
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 49 (12), 2345-2352
- https://doi.org/10.1172/jci106453
Abstract
The characteristics of the disappearance of radioiodinated synthetic human calcitonin from plasma have been studied in man. After single injection the disappearance curve was multiexponential. The number of exponentials of the theoretical curve fitting the best with the experimental data varied individually. Metabolic clearance rate was determined both from single injection and constant infusion studies, and fast initial distribution volume from the former. Metabolic clearance rate values in normal man calculated from constant infusion studies were 82.3 ±3.4 ml/min per m2. Values derived from single injection studies were similar, 77.0 ±4.7 ml/min per m2. These results were compared to those obtained in end stage, renal failure patients. Metabolic clearance rate was considerably lower and volume of fast initial distribution slightly larger in that group. This fact emphasizes the important role of kidneys in the utilization and/or the degradation of human calcitonin.Keywords
This publication has 22 references indexed in Scilit:
- Metabolic clearance and production rates of human growth hormoneJCI Insight, 1969
- Metabolic clearance rate of radioiodinated human growth hormone in manJCI Insight, 1969
- Derivation of a three compartment model describing disappearance of plasma insulin-131I in manJCI Insight, 1969
- A RADIOIMMUNOASSAY FOR HUMAN CALCITONIN MThe Lancet, 1969
- [Inactivation of thyrocalcitonin by various organs].1969
- Menschliches Calcitonin I. Isolierung und CharakterisierungHelvetica Chimica Acta, 1968
- Insulin delivery rate into plasma in normal and diabetic subjectsJCI Insight, 1968
- Metabolic clearance and production rates of human luteinizing hormone in pre- and postmenopausal womenJCI Insight, 1968
- Review: The Use of Isotopic Steroids for the Measurement of Production Rates in Vivo1Journal of Clinical Endocrinology & Metabolism, 1963
- INSULIN-I131 METABOLISM IN HUMAN SUBJECTS: DEMONSTRATION OF INSULIN BINDING GLOBULIN IN THE CIRCULATION OF INSULIN TREATED SUBJECTS 1JCI Insight, 1956