An improved synthesis of 24,24-difluoro-1.ALPHA.,25-dihydroxyvitamin D3 from vitamin D2.

1 January 1992

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 40 (6), 1662-1664
https://doi.org/10.1248/cpb.40.1662

Abstract

An improved synthesis of a highly potent vitamin D₃ analog, 24, 24-difluoro-1α, 25-dihydroxyvitamin D₃ has been accomplished. The total yield was 9.3% from inexpensive vitamin D₂ in 11 steps.

Keywords

ANALOG
INEXPENSIVE
ACCOMPLISHED
DIFLUORO
VITAMIN D2
1.ALPHA
IMPROVED SYNTHESIS

Cited by 15 articles