T Cell Variant of Chronic Lymphocytic Leukaemia with Chromosome Abnormality and Defective Response to Mitogens
- 1 August 1976
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 33 (4), 459-468
- https://doi.org/10.1111/j.1365-2141.1976.tb03564.x
Abstract
Summary. Lymphocytes from a patient with chronic lymphocytic leukaemia, in whom therapy was ineffective, were defined as thymus-derived (T) cells by membrane markers (sheep erythrocyte rosettes, complement rosettes, surface immunoglobulin). The lymphocytes responded weakly to two mitogens, phyto-haemagglutinin and the calcium ionophore A23187, but not to concanavalin A. Cytogenetic studies of leukaemic cells from unstimulated and mitogen-stimulated cultures revealed an abnormal karyotype with 45 chromosomes and multiple rearrangements. The T cell variant of classical chronic lymphocytic leukaemia is relatively rare; additional reports are needed to determine if the clinical course is typically less benign than in the common B cell variety, or whether this patient simply represented a late, unresponsive phase of the disease.This publication has 20 references indexed in Scilit:
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