Mono-ortho-chlorinated chlorobiphenyls: Toxicity and induction of 7-ethoxyresorufinO-deethylase (EROD) activity in chick embryos
- 1 April 1990
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 64 (3), 188-192
- https://doi.org/10.1007/bf02010724
Abstract
Six mono-ortho-chlorinated chlorobiphenyls were compared regarding their toxicity and 7-ethoxyresorufinO-deethylase (EROD)-inducing potency in chick embryos. Three of the tested chlorobiphenyls have a chloro substituent adjacent to theortho-chlorine, and these congeners were about ten times more potent than the three having ameta-hydrogen adjacent to theortho-chlorine. These more toxic mono-ortho-chlorinated congeners were, however, about three orders of magnitude less toxic and less potent as EROD inducers in chick embryos than 3,3′,4,4′,5-pentachlorobiphenyl in a previous similar study. Malformed eyes and beaks, degenerative hepatic lesions and subcutaneous as well as pericardial edema were detected in embryos exposed to the mono-ortho-chlorine-substituted congeners, as was previously found after exposure to the most toxic non-ortho-chlorinated, coplanar chlorobiphenyls. It is concluded that the monoortho-chlorinated chlorobiphenyls are considerably less toxic and less potent as EROD inducers than the most toxic coplanar ones. Owing to their relatively high concentrations in technical preparations of polychlorinated biphenyls (PCBs) the mono-ortho-chlorine-substituted congeners may, however, contribute to the overall toxicity of PCBs.This publication has 26 references indexed in Scilit:
- Toxic potential of non-ortho and mono-ortho coplanar PCBs in commercial PCB preparations: “2,3,7,8-T4 CDD toxicity equivalence factors approach”Bulletin of Environmental Contamination and Toxicology, 1988
- Effects of the TCDD congeners 3,3′,4,4′-tetrachlorobiphenyl and 3,3′,4,4′-tetrachloroazoxybenzene on lymphoid development in the bursa of fabricius of the chick embryoToxicology and Applied Pharmacology, 1988
- Highly toxic coplanar PCBs: Occurrence, source, persistency and toxic implications to wildlife and humansEnvironmental Pollution, 1987
- Ah receptor for 2,3,7,8‐ tetrachlorodibenzo‐p‐Dioxin: Ontogeny in chick embryo liverJournal of Biochemical Toxicology, 1986
- Polychlorinated aromatic hydrocarbon lethality, mixed-function oxidase induction, and uroporphyrinogen decarboxylase inhibition in the chick embryo: Dissociation of dose-response relationships*1Toxicology and Applied Pharmacology, 1985
- Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of ActionCRC Critical Reviews in Toxicology, 1984
- Toxicity and distribution in chick embryos of 3,3′,4,4′-tetrachlorobiphenyl injected into the eggsToxicology, 1983
- Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptorChemico-Biological Interactions, 1982
- Embryotoxicity of 3,3?,4,4?-tetrachloroazobenzene and 3,3?,4,4?-tetrachioroazoxybenzene in the chick embryoArchives of Environmental Contamination and Toxicology, 1982
- Etiology of chick edema disease.Environmental Health Perspectives, 1973