Respiratory Acidosis
- 1 November 1965
- journal article
- abstracts
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 116 (5), 689-698
- https://doi.org/10.1001/archinte.1965.03870050043008
Abstract
RESPIRATORY ACIDOSIS is the abnormal physiologic state which occurs when the blood level of dissolved CO2, and consequently of carbonic acid, is elevated. The term respiratory acidosis will be used to apply even to those conditions in which the blood is not abnormally acid in reaction, following a clinical usage of the term. Nevertheless it should be clear that the major problem in hypercapnic states lies in the elevation of CO2 tension in blood and tissues, rather than in the varying degree of acidosis of the blood. Respiratory acidosis is unique in that the acid (as dissolved CO)2 penetrates cells and cerebrospinal fluid rapidly, rather than with the slower movement characteristic of ions. Consequently intracellular acidosis occurs more rapidly. Alveolar ventilation and CO2 production determine the alveolar and therefore arterial and tissue levels of Pco2. The following equation expresses this relationship in simplified form. where Vco2 is the CO2 outputThis publication has 29 references indexed in Scilit:
- TISSUE AND RENAL RESPONSE TO CHRONIC RESPIRATORY ACIDOSIS*JCI Insight, 1959
- The Syndrome of Alveolar Hypoventilation and Diminished Sensitivity of the Respiratory CenterNew England Journal of Medicine, 1957
- THE WORK OF BREATHING AND ITS RELATION TO RESPIRATORY ACIDOSISAnnals of Internal Medicine, 1954
- Effect of Carbonic Anhydrase Inhibition on RespirationAmerican Journal of Physiology-Legacy Content, 1954
- Human Electrocardiogram During and After Inhalation of Thirty Per Cent Carbon DioxideJournal of Applied Physiology, 1953
- Effect of Plasma CO2 Tension on Renal Tubular Reabsorption of BicarbonateAmerican Journal of Physiology-Legacy Content, 1953
- Effect of Carbon Dioxide Excess on Contractile Force of Heart, In SituAmerican Journal of Physiology-Legacy Content, 1953
- Effect of Increased Carbon Dioxide Concentrations on Fixed Acid Production in VitroAmerican Journal of Physiology-Legacy Content, 1953
- Ventricular Fibrillation Following a Rapid Fall in Alveolar Carbon Dioxide ConcentrationAmerican Journal of Physiology-Legacy Content, 1952
- THE USE OF ARTIFICIAL RESPIRATION IN PULMONARY EMPHYSEMA ACCOMPANIED BY HIGH CARBON DIOXIDE LEVELS 1JCI Insight, 1951